Development of method of exposure and determination of active pharmaceutical ingredients in composition of stomatological films

Methodology of qualitative and quantitative determination of operating substances – decametoxine
and lidocaine of hydrochloride –in composition of the new combined medicinal means for prophylaxis
and treatment of inflammatory diseases of cavity of mouth is worked out .
The terms of chromatography research with the use of HPLC method providing sufficient selectivity
and efficiency of division of components of stomatological films is offered.
It was found that quantity of components of stomatological films is within safe limits, and metrology
descriptions of method make it possible to recommend it for the use in control of quality of
films. It is set that quantity of decametoxine in 1 sm2 of medicinal films was 8.87 mcg (at the norm
of 7.98–9.76 mkg/sm2), lidocaine of hydrochloride – 177.5 mcg (at norm 159.75–195.25 mkg/sm2).
Offered terms of chromatography research with the use of method of HPLC provide sufficient selectivity
and efficiency of division. Approximate time of retaining of peak of decametoxine makes
18.4 min, lidocaine of hydrochloride – 13.5 min. Time of retaining of peaks of decametoxine and
lidocaine of hydrochloride of the investigated solution and the test solution did not exceed 2%.