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Исследование эффективности вагинальных суппозиториевс противовоспалительной и противомикробной активностью на модели экспериментального вагинита

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Аннотация

The study has been carried out in 35 female Vistar rats weighing 200-220 g. The animals were divided into 5 groups: 1 - intact animals, control; 2 - animals with modeled experimental vaginitis (EV); 3 - ЕV + base (B); 4 - ЕV + new combined investigated medicinal product with anti-inflammatory and antimicrobial effect in the form of vaginal suppositories (ID); 5 - ЕV + reference medicinal product neo-penotran in the form of vaginal suppositories (RP). The investigated medicinal product contained ibuprofen, clotrimazol and metronidazol in the form of suppositories. neo-penotran contained miconazol and metronidazol. Both medicinal products included the identical base: witepsol. 5 days after modeling EB a histological examination of rats’ vagina was carried out.While modeling EB in 2 group of animals an evident atrophy of vaginal mucosa epithelium, desquamation of the areas of dead mucosa and an evident inflammatory reaction (macrophage and neutrophil infiltration). In groups 4 and 5 the drugs’ effect was manifested as rejection of a dead layer into the organ lumen. A statistically significant reduction of structural changes in the vaginal wall (total index, epithelial thickness) was detected in group 4 and there was no true difference in group 5.The investigated medicinal product’s effect consisted in a faster rejection and elimination of the damaged epithelium and a formation of favorable conditions for the reconstructive process. A conclusion about the absence of the drug influence in group 5 was made, because an increase of the average epithelial thickness resulted from a mucosal edema, but not from an activation of reconstructive processes.

Об авторах

И. В. Ниженковская
Национальный медицинский университет имени А.А. Богомольца
Украина


Л. В. Онищук
Национальный медицинский университет имени А.А. Богомольца
Украина


С. И. Савосько
Национальный медицинский университет имени А.А. Богомольца
Украина


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Для цитирования:


Ниженковская И.В., Онищук Л.В., Савосько С.И. Исследование эффективности вагинальных суппозиториевс противовоспалительной и противомикробной активностью на модели экспериментального вагинита. Рецепт. 2018;(6):834-842.

For citation:


Nizhenkovska I..., Onyshchuk L..., Savosko S. Efficacy study of vaginal suppositorieswith anti-inflammatory and antimicrobial effect on a model of experimental vaginitis. Recipe. 2018;(6):834-842. (In Russ.)

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