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Применение антиоксидантов при острой ишемии. Обзор литературы

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Аннотация

В прогрессировании любого острого патологического процесса огромную роль играет развитие острой гипоксии. Терапия острой ишемии сложна, разнонаправленна и многогранна. Несмотря на внедрение в практику новых хирургических, эндоскопических и медикаментозных методов лечения, летальность в группе пациентов с тяжелой кровопотерей остается высокой и составляет от 15% до 80%. Основной причиной летальности является прогрессирование полиорганной недостаточности. В патогенезе острой постгеморрагической гипоксии в последнее время значительное место уделяется нарушению свободнорадикальных процессов, что сопровождается поступлением продуктов перекисного окисления в системный кровоток и усугубляет органную дисфункцию. Считается, что некомпенсированная активация перекисного окисления при острой кровопотере является важным звеном в патогенезе полиорганной недостаточности, определяющей исход заболевания. Остается не изученным нарушение баланса антипрооксидантной системы организма пациентов с различной интенсивностью кровотечения и степенью кровопотери, не определены методы медикаментозной коррекции развивающихся свободнорадикальных нарушений. Все вышеизложенное и определяет актуальность, научно-практическую значимость проведения исследований по оптимизации патогенетического лечения пациентов данной категории с учетом состояния баланса антипрооксидантных систем организма.

Об авторе

С. Л. Зыблев
Республиканский научно-практический центр радиационной медицины и экологии человека
Беларусь

Гомель



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Для цитирования:


Зыблев С.Л. Применение антиоксидантов при острой ишемии. Обзор литературы. Рецепт. 2019;(5):752-760.

For citation:


Zyblev S. Use of Antioxidants in Acute Ischemia. Literature Review. Recipe. 2019;(5):752-760. (In Russ.)

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