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Влияние альфа-липоевой кислоты на метаболизм глюкозы, маркеры воспаления и липидный спектр крови

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Аннотация

В статье представлен обзор данных литературы по влиянию альфа-липоевой кислоты (АЛК) на метаболизм глюкозы, липидный спектр крови и маркеры воспаления, окислительный стресс. По данным исследований продемонстрированы прямые или косвенные эффекты АЛК по снижению уровня глюкозы и повышению чувствительности тканей к инсулину. Описаны эффекты АЛК по снижению всасывания жира в кишечнике, снижению биосинтеза и усилению метаболизма липидов. Применение АЛК замедляет прирост массы тела и уровня холестерина, триглицеридов и липопротеидов низкой плотности (ЛПНП) в плазме крови как при индуцированном диабете, так и без диабета. Наряду с диетой с высоким содержанием жиров применение АЛК значительно снижало уровень общего холестерина, ЛПНП, липопротеидов очень низкой плотности и триглицеридов в крови, а также приводило к значимому повышению уровня липопротеидов высокой плотности. У пациентов с избыточным весом наблюдалось снижение концентраций С-реактивного белка и фактора некроза опухоли-α после приема АЛК (800 мг/день) в течение 4 месяцев при одновременном повышении уровня адипонектина. Применение АЛК в течение 10 недель улучшало профиль факторов системного воспаления и снижало риск развития сердечно-сосудистых заболеваний у здоровых женщин с избыточным весом. Таким образом, применение АЛК патогенетически оправданно при ряде заболеваний и состояний, особенно у пациентов с метаболическим синдромом, поскольку АЛК способствует значительному подавлению гипергликемических и гиперлипидемических состояний, снижению уровней провоспалительных маркеров и уменьшению проявлений окислительного стресса.

Об авторе

Л. В. Якубова
Гродненский государственный медицинский университет
Беларусь

Гродно



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Для цитирования:


Якубова Л.В. Влияние альфа-липоевой кислоты на метаболизм глюкозы, маркеры воспаления и липидный спектр крови. Рецепт. 2019;(5):744-751.

For citation:


Yakubova L. The Effect of Alpha Lipoic Acid on Glucose Metabolism, Markers of Inflammation and Blood Lipids. Recipe. 2019;(5):744-751. (In Russ.)

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