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Многоликость пост-COVID-синдрома и возможности коррекции постинфекционной иммуносупрессии

https://doi.org/10.34883/PI.2021.24.5.001

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Аннотация

В обзорной статье приводятся определение пост-COVID-синдрома и его классификации. Основные клинические проявления пост-COVID-синдрома включают в себя множество состояний и симптомов, частота проявлений которых варьирует в зависимости от тяжести острой инфекции и периода наблюдения. Наиболее распространенный симптом пост-COVID-синдрома – усталость, встречающаяся с частотой от 17,5% до 72%. По данным Dennis A. и соавт., МРТ выявила поражение хотя бы одного органа в 70% случаев пост-COVID-синдрома через 4 месяца после выздоровления от острой инфекции. Длительное воспаление, иммунная дисрегуляция играют ключевую роль в развитии большинства пост-COVID-проявлений, безусловно, являясь не единственным патофизиологическим механизмом их развития. Если воспалительный ответ слишком подавлен, то пациент, сумев «пережить» первоначальный гипервоспалительный цитокиновый шторм и прогрессирование полиорганной недостаточности, может вступить в стадию затяжной иммуносупрессии, известной как синдром стойкого воспаления, иммуносупрессии и катаболизма, что является одной из предполагаемых причин стойкого пост-COVID-синдрома. Приведена работа, в которой рассматривается возможность применения в лечении инфекции SARS-CoV-2 инозина пранобекса, который зарегистрирован как противовирусный иммуномодулирующий препарат более чем в 70 странах мира.

Об авторах

Л. В. Якубова
Гродненский государственный медицинский университет
Беларусь

Гродно



Л. Н. Смирнова
Гродненский государственный медицинский университет
Беларусь

Гродно



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Для цитирования:


Якубова Л.В., Смирнова Л.Н. Многоликость пост-COVID-синдрома и возможности коррекции постинфекционной иммуносупрессии. Рецепт. 2021;(5):614-624. https://doi.org/10.34883/PI.2021.24.5.001

For citation:


Yakubova L., Smirnova L. Post-COVID Syndrome Variety and Possibilities of Correction of Post-Infectious Immunosuppression. Recipe. 2021;(5):614-624. (In Russ.) https://doi.org/10.34883/PI.2021.24.5.001

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