Preview

Рецепт

Расширенный поиск

Анализ влияния омега-3-полиненасыщенных жирных кислот на воспаление: патогенетические механизмы, эффектыи клиническое значение их применения

https://doi.org/10.34883/PI.2020.23.6.007

Полный текст:

Аннотация

Воспаление – это состояние, которое сопутствует ряду заболеваний человека. Оно затрагивает множество типов клеток, химических медиаторов и взаимодействий. ЭПК и ДГК являются основными ω-3 ПНЖК, содержащимися в жирной рыбе и рыбьем жире. Есть клинические исследования, которые показывают, что эти ЖК способны частично ингибировать ряд аспектов воспаления. В статье приведен анализ литературных источников относительно вопросов патогенетических механизмов воспалительного и аутоиммунного процессов, системного воспаления, механизм действия ω-3 жирных кислот в воспалительной системе и принципы использования этих жирных кислот для лечения заболеваний с воспалительным компонентом. Дозозависимый эффект ω-3 ПНЖК на воспалительные реакции недостаточно хорошо описан в литературных источниках, но очевидно, что для достижения противовоспалительного эффекта необходима доза не менее 2 г в день. Механизм противовоспалительного действия ω-3 ПНЖК (ЭПК и ДГК) заключается в их влиянии на метаболизм арахидоновой кислоты. Следует заметить, что оптимального баланса ЖК в организме человека, даже при увеличении в рационе ω-3, невозможно достичь без уменьшения потребления жиров с содержанием ω-6 ЖК.

Об авторах

Л. ф Матюха
Национальная медицинская академия последипломного образования имени П.Л. Шупика
Украина


Е. Ю. Гончарук
Национальная медицинская академия последипломного образования имени П.Л. Шупика
Украина


Список литературы

1. Bang H.O., Dyerberg J., Nielsen A.B. (June 1971) Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet 1 (7710): 1143– 1145. PMID 4102857.

2. Kromann N., Green A. (1980) Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950–1974. Acta medica Scandinavica 208 (5): 401–406. PMID 7457208

3. Sheppard K.W., Cheatham C.L. (2018). Omega-6/omega-3 fatty acid intake of children and older adults in the US: dietary intake in comparison to current dietary recommendations and the Healthy Eating Index. Lipids in health and disease, 17(1), 43.

4. Husted K.S., Bouzinova E.V. (2016). The importance of n-6/n-3 fatty acids ratio in the major depressive disorder. Medicina, 52(3), 139–147.

5. Korotkova M., Telemo E., Yamashiro Y., Hanson L.A., Strandvik B. The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin. Clin Exp Immunol. 2004;137: 2: 237–244.

6. Grechko A.V., Evdokimov E.A., Kotenko O.N., Krylov K.Y., Kryukov E.V., Luft V.M., Popova T.S. (2020). Nutritional support for patients with COVID-19 coronavirus infection. Clinical nutrition and metabolism, 1(2), 56–91.

7. Zhang Z, Fulgoni VL, Kris-Etherton PM, Mitmesser SH. Dietary Intakes of EPA and DHA Omega-3 Fatty Acids among US Childbearing-Age and Pregnant Women: An Analysis of NHANES 2001–2014. Nutrients. 2018 Mar 28;10(4):416. doi: 10.3390/nu10040416. PMID: 29597261; PMCID: PMC5946201.

8. Zhao Y, Wang C. Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: A meta-analysis of randomized control trials in China. Medicine (Baltimore). 2018; 97(16):e0472. doi:10.1097/MD.0000000000010472

9. Calder P.C. The relationship between the fatty acid composition of immune cells and their function, Prostaglandins Leukot. Essent. Fat. Acids 79 (2008) 101–108.

10. Тorrecillas S., Román L., Rivero-Ramírez F., Caballero M.J., Pascual C., Robaina L., Montero D. (2017) Supplementation of arachidonic acid rich oil in European sea bass juveniles (Dicentrarchus labrax) diets: Effects on leucocytes and plasma fatty acid profiles, selected immune parameters and circulating prostaglandins levels. Fish & Shellfish Immunology, 64, 437–445.

11. De Carvalho C.C., Caramujo M.J. (2018) The various roles of fatty acids. Molecules, 23(10), 2583.

12. Gutiérrez S., Svahn S.L., Johansson M.E. (2019) Effects of omega-3 fatty acids on immune cells. International journal of molecular sciences, 20(20), 5028.

13. Innes J.K., Calder P.C. (2018) Omega-6 fatty acids and inflammation. Prostaglandins, Leukotrienes and Essential Fatty Acids, 132, 41–48.

14. Gomaa A.M., Abd El-Aziz E.A. (2016) Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat model. Pathophysiology, 23(4), 295–301.

15. Sperling R.I., Benincaso A.I., Knoell C.T., Larkin J.K., Austen K.F., Robinson D.R. Dietary w-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J. Clin. Investig. 91 (1993) 651–660.

16. Akerele O.A., Cheema S.K. A diet enriched in longer chain omega-3 fatty acids reduced placental inflammatory cytokines and improved fetal sustainability of C57BL/6 mice. Prostaglandins, Leukotrienes and Essential Fatty Acids, 137 (2018): 43–51.

17. Rees D., Miles E.A., Banerjee T., Wells S.J., Roynette C.E., Wahle K.W.J.W., Calder P.C. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am. J. Clin. Nutr. 83 (2006) 331–342.

18. Fillah A.M., Normasari R., Rachmawati D.A. (2017) The Difference in Lemuru Fish Oil Duration of Administration on Connective Tissue Fibroblast Cell Count in Rheumatoid Arthritis Rat Model. JOURNAL AMS, 3(2), 1–5.

19. ISO 690

20. Prego-Dominguez J., Hadrya F., Takkouche B. (2016) Polyunsaturated fatty acids and chronic pain: a systematic review and meta-analysis. Pain physician, 19(8), 521–35.

21. Hudert C.A., Weylandt K.H., Lu Y., Wang J., Hong S., Dignass A., Serhan C.N., Kang J.X. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc. Natl. Acad. Sci. U. S. A., 103 (2006) 11276–11281.

22. Lee J., Moraes-Vieira P. M., Castoldi A., Aryal P., Yee E.U., Vickers C., Kahn B.B. (2016) Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses. Journal of biological chemistry, 291(42), 22207–22217.

23. Gobbetti T., Dalli J., Colas R.A., Canova D.F., Aursnes M., Bonnet D., Serhan C.N. (2017) Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proceedings of the National Academy of Sciences, 114(15), 3963–3968.

24. Hussein S., Abd Elazem M.B., Mostafa Ali H.A. (2019) The potential anti-inflammatory effect of Omega-3 polyunsaturated fatty acids on experimentally induced ulcerative colitis in rats. Benha Veterinary Medical Journal, 37(1), 237–244.

25. Calder P.C., Ahluwalia N., Albers R., Bosco N., Bourdet-Sicard R., Haller D., Holgate S.T., Jonsson L.S., Latulippe M.E., Marcos A., Moreines J., M’Rini C., Muller M., Pawelec G., van Neerven R.J.J., Watzl B., Zhao J. A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Br. J. Nutr. 109 (Suppl. 1) (2013) S1–S34.

26. Calder P.C., Albers R., Antoine J.M., Blum S., Bourdet-Sicard R., Ferns G.A., Folkerts G., Friedmann P.S., Frost G.S., Guarner F., Løvik M., Macfarlane S., Meyer P.D., M’Rabet L., Serafini M., van Eden W., van Loo J., Vas Dias W., Vidry S., Winklhofer-Roob B.M., Zhao J. Inflammatory disease processes and interactions with nutrition. Br. J. Nutr. 101 (2009) S1–S45.

27. Calder P.C., Albers R., Antoine J.M., Blum S., Bourdet-Sicard R., Ferns G.A., Folkerts G., Friedmann P.S., Frost G.S., Guarner F., Løvik M., Macfarlane S., Meyer P.D., M’Rabet L., Serafini M., van Eden W., van Loo J., Vas Dias W., Vidry S., Winklhofer-Roob B.M., Zhao J. Inflammatory disease processes and interactions with nutrition. Br. J. Nutr. 101 (2009) S1–S45.

28. Yan Y., Wang Z., Greenwald J., Kothapalli K.S.D., Park H.G., Liu R., Brenna J.T. (2017) BCFA suppresses LPS induced IL-8 mRNA expression in human intestinal epithelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids, 116, 27–31.

29. Chavali S., Forse R.A. (2018) The role of omega-3 polyunsaturated fatty acids on immune responses during infection and inflammation. Diet, Nutrition, and Immunity, 179–186.

30. Zehr K.R., Walker M.K. (2018) Omega-3 polyunsaturated fatty acids improve endothelial function in humans at risk for atherosclerosis: A review.Prostaglandins & other lipid mediators, 134, 131–140.

31. Baena-Gómez M.A., de la Torre-Aguilar M.J., Aguilera-García C.M., Olza J., Pérez-Navero J.L., Gil-Campos M. (2016) Inflammatory response using different lipid parenteral nutrition formulas in children after hematopoietic stem cell transplantation. Nutrition and cancer, 68(5), 804–810.

32. Gomaa A.M., Abd El-Aziz E.A. (2016) Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat model. Pathophysiology, 23(4), 295–301.

33. Babcock T.A., Novak T., Ong E., Jho D.H., Helton W.S., Espat N.J. Modulation of lipopolysaccharide-stimulated macrophage tumor necrosis factor-a production by w−3 fatty acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10, J. Surg. Res. 107 (2002) 135–139.

34. Novak T.E., Babcock T.A., Jho D.H., Helton W.S., Espat N.J. NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am. J. Physiol. 284 (2003) L84–L89.

35. Zhao Y., Joshi-Barve S., Chen L.H. Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J. Am. Coll. Nutr. 23 (2004) 71–78.

36. Baker E.J., Yusof M.H., Yaqoob P., Miles E.A., Calder P.C. (2018) Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti- atherosclerotic actions. Molecular Aspects of Medicine, 64, 169–181.

37. Rehman K., Zulfakar M.H. (2017) Novel fish oil-based bigel system for controlled drug delivery and its influence on immunomodulatory activity of imiquimod against skin cancer. Pharmaceutical research, 34(1), 36–48.

38. Sierra S., Lara-Villoslada F., Comalada M., Olivares M., Xaus J. Dietary eicosapentaenoic acid and docosahexaenoic acid equally incorporate as docosahexaenoic acid but differ in inflammatory effects. Nutrition 24 (2008) 245–254.

39. Sierra S., Lara-Villoslada F., Comalada M., Olivares M., Xaus J. Dietary eicosapentaenoic acid and docosahexaenoic acid equally incorporate as docosahexaenoic acid but differ in inflammatory effects. Nutrition 24 (2008) 245–254.

40. Gioxari A., Kaliora A.C., Marantidou F., Panagiotakos D.P. (2018) Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis. Nutrition, 45, 114–124.

41. Baker E.J., Valenzuela C.A., De Souza C.O., Yaqoob P., Miles E.A., Calder, P.C. (2020) Comparative anti-inflammatory effects of plant-and marine- derived omega-3 fatty acids explored in an endothelial cell line. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(6), 158662.

42. Soveyd N., Abdolahi M., Djalali M., Hatami M., Tafakhori A., Sarraf P., Honarvar N.M. (2017) The combined effects of ω-3 fatty acids and nano- curcumin supplementation on intercellular adhesion molecule-1 (ICAM-1) gene expression and serum levels in migraine patients. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 16(10), 1120–1126.

43. Baker E.J., Valenzuela C.A., van Dooremalen W.T., Martínez‐Fernández L., Yaqoob P., Miles E.A., Calder P.C. (2020) Gamma‐Linolenic and Pinolenic Acids Exert Anti‐Inflammatory Effects in Cultured Human Endothelial Cells Through Their Elongation Products. Molecular Nutrition & Food Research, 64(20), 2000382.

44. Calder Philip C. Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45.5 (2017): 1105– 1115.

45. Chimen, Myriam Monocyte subsets coregulate inflammatory responses by integrated signaling through TNF and IL-6 at the endothelial cell interface. The Journal of Immunology, 198.7 (2017): 2834–2843.

46. Gioxari A, Kaliora AC, Marantidou F, Panagiotakos DP. Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis. Nutrition. 2018 Jan; 45:114–124.e4. doi: 10.1016/j.nut.2017.06.023. Epub 2017 Jul 8. PMID: 28965775.

47. Holen E, Araujo P, Sissener NH, Rosenlund G, Waagbø R. A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes. Fish Shellfish Immunol. 2018 Jan; 72:57–68. doi: 10.1016/j.fsi.2017.10.040. Epub Dec 5, 2017. Erratum in: Fish Shellfish Immunol. 2018 Dec; 83:449. PMID: 29080687.

48. Iwase H, Kariyazono H, Arima J, Yamamoto H, Nakamura K. Nutritional Effect of Oral Supplement Enriched in ω-3 Fatty Acids, Arginine, RNA on Immune Response and Leukocyte-platelet Aggregate Formation in Patients Undergoing Cardiac Surgery. Nutr Metab Insights. 2014 May 25; 7:39–46. doi: 10.4137/NMI.S13810. PMID: 24932104; PMCID: PMC4051814.

49. Aida T, Furukawa K, Suzuki D, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Miyazaki M. Preoperative immunonutrition decreases postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy. Surgery. 2014 Jan; 155(1):124–33. doi: 10.1016/j.surg.2013.05.040. Epub 2013 Oct 25. PMID: 24589090.

50. Matolinec N.V. (2016) Rol’ i mesto omega-3 zhirnyh kislot v regulyacii sindroma sistemnogovospalitel’nogo otveta u pacientov, poluchayushchih intensivnuyu terapiyu [Role and place of omega-3 fatty acids in regulation of the syndrome of systemic inflammatory response in intensive care patients]. Medicina neotlozhnyh sostoyanij, 8: 79.

51. Gorshkov N. (2019) Omega-3 polinenasyshchennye zhirnye kisloty v intensivnoj terapii i kardiohirurgii [Omega-3 polyunsaturated fatty acids in intensive care and cardiac surgery]. Sovremennye tendencii razvitiya obrazovaniya, nauki i tekhnologij, pp. 168–171.


Для цитирования:


Матюха Л.ф., Гончарук Е.Ю. Анализ влияния омега-3-полиненасыщенных жирных кислот на воспаление: патогенетические механизмы, эффектыи клиническое значение их применения. Рецепт. 2020;(6):863-871. https://doi.org/10.34883/PI.2020.23.6.007

For citation:


Matyukha .L., Goncharuk .E. Analysis of the Influence of Omega 3 Polyunsaturated Fatty Acids on Inflammation: Pathogenetic Mechanisms, Effects and Clinical Significance of their Use. Recipe. 2020;(6):863-871. (In Russ.) https://doi.org/10.34883/PI.2020.23.6.007

Просмотров: 17


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1993-4882 (Print)
ISSN 2414-2263 (Online)